Significant hypersensitivity reactions together with anaphylaxis and angioedema are actually documented with copyright®.??? ? ???????, ?????? ??? ????? ????? ??????????. ? ???? ? ???? ???? ??????? ? ???, ??? ???????????? ??????, ?? ????? ????????? ???????????? ????????????, ??????? ??? ????????.??? ??? ???????? ??????? ???????® ?? ????????? ?????